FCPS part 1 Medicine solved mcqs with explanation Q21

Q21: Dose of Gentamicin is reduced in the elderly due to:

a) Liver failure

b) Reduced renal function

c) Decreased GI absorption

d) Decreased metabolism

Correct Answer: b

Explanation:

Gentamicin is one of the Aminoglycosides. In elderly like all other body functions renal function is also slightly reduced. For Aminoglycosides such as Gentamicin, remember the following three important side effects:

• Ototoxicity
• Nephrotoxicity
• Neurmuscular dysfunction
• Teratogenic

Aminoglycosides are used for severe gram negative rod infections. Since they require oxygen for their uptake, they are therefore ineffective against anaerobes.