FCPS part 1 Medicine solved mcqs with explanation Q7

Q7: Which of the followings is P450 inducer?

a) Isoniazid

b) Phenobarbitone

c) Ketoconazole

d) Cimetidine

Correct Answer: b

Explanation:

Phenobarbitone is one of the anticonvulsant. Anticonvulsants in general are inducers of Cytochrome P450 system. Others inducers of P450 are: Rifampin, Griseofulvin, Carbamazepine, Phenytoin.

For inhibitors of P450 remember the Mnemonic: SICK EGgs inhibit your appetite.

S: Sulfonamides

I: Isoniazid

C: Cimetidine

K: Ketoconazole

E: Erythromycin

G: Grapefruit juice.