FCPS part 1 Medicine solved mcqs with explanation Q9

Q9: Gastroesophageal junction competence is increased by:

a) Lying supine

b) Paralysis of the diaphragm

c) Use of Morphine

d) Use of Metoclopromide

e) Increased intra-abdominal pressure

Correct Answer: d

Explanation:

Metoclopromide is D2 receptor antagonist that increased the resting tone of GIT, increases contractility & increases Lower esophageal junction tone. It is clinically used for Diabetic & post-surgery gastroparesis. Toxicity includes parkinsonian effects, restlessness, drowsiness, fatigue, depression, nausea, diarrhea. Contraindicated in patients with small bowel obstruction.

Other option under this question actually decrease the GE junction tone.